The small church at the corner near the main entrance to San Callisto is widely known as the Church of Domine Quo Vadis, though this is not its official name. Its reputation comes from a famous legend connected to Saint Peter, one of the most important figures in early Christianity.
According to tradition, this church stands on the very spot where Saint Peter, fleeing persecution in ancient Rome, had a powerful vision. As Peter tried to escape the city, he saw the risen Christ and asked him, "Domine, quo vadis?" which means "Lord, where are you going?" This moment is said to have inspired Peter to return to Rome and face his fate.
The building that stands today was constructed in 1637. Visitors who step inside will find a special relic: a copy of a stone that displays the footprints of Jesus. The story goes that these marks were left when Christ appeared to Peter. The original stone, however, is preserved in the Church of San Sebastiano, which is located further along the historic Appian Way.
Source - https://en.wikipedia.org/wiki/Santa_Maria_in_Palmis
Built in 81 AD by the emperor Domitianus in dedication to his brother Titus, who died earlier that year and reigned as emperor from 79-81, overseeing the opening of the Colosseum in 80 and the eruption of Mt Vesuvius the previous year.
This church can be an interesting deviation if you are passing through its neighbourhood. It is believed to be the grave of the Saints Ciro and Giovanni, killed during the time of the Emperor Diocletian. The original name was Abba Cyrus and through Appaciro and then Appacero it finally became Pacera, very close to today's Passera. The building is on top of a 3rd century building still visible in the lower floor and in the underground. The main part of the building dates back to the 9th century as do the frescoes on the higher floor. Some of the frescoes have been restored. Downstairs there is a small quadrangular room and the underground, where the remains of the two Saints are supposed to be. There are still visible 3rd century traces of Roman frescoes; in front of the stair you can enjoy a small bird, the Justice, and an athlete while in the vault some eight apex stars. Bus 128,780,781,775 (first stop in Via della Magliana).
A 5th-century basilica, simply and attractively decorated. The wooden door, of which 18 carved panels of scenes from the Bible survive, is believed to date from the church's construction.
An example of urban planning that goes back to Pope Julius II, who, in 1508, envisioned it as a street that would connect all major government buildings. It is around a kilometer long and is in a straight line, an unusual feature for the time. It is lined with some interesting palaces but these days is more known for its antique shops. Via Giulia runs parallel with and one block from the River Tiber.
On the other side of the Via dei Fori Imperiali to the Roman Forum. Well-preserved market area that doubled as a way of stopping the Quirinal Hill from collapsing. Below in the Forum is Trajan's Column, built in 113 with reliefs depicting the Emperor Trajan's vistories in battle.
This palace of the 16th century was erected by the famous Medici family. It was the residence of Cardinals Giovanni and Giuliano Medici, later Pope Leo X. and Clement VII. Catherine de Medici, Pope Clement VII's niece lived here until her marriage in 1553 with Prince Henry, the son of King Francis I of France. The palace is named after Madama Margerita of Austria, the illegitimate daughter of Emperor Charles V. Since 1871 it has been the seat of the Italian Senate.
The western end of the ancient Via Appia road connecting Rome to Brindisi in the heel of Italy, and as such the third world heritage site in Rome together with the Old Center and the Vatican. As such it's an important historical location, even if the remains of the gate aren't as impressive as the city's major sites. As Via Appia heads southeast out of Rome, and after a few kilometers the route is officially named Via Appia Antica and starts looking more historical: it gets narrow as a city street, the asphalt is replaced by a rock surface and the road is lined with parks and park-like areas and walled old buildings. This section has been described as the world's longest museum.
The chains that allegedly held St. Peter are displayed in a case before the altar. More importantly, contains the impressive statue of Moses by Michelangelo. It's close to the Colosseum, but a little hard to find. Take the steps opposite the Colosseum on Via dei Fori Imperiali, cross the road at the top and seek directions. Also reachable through steps to the right leading off Via Cavour.
This archaeological site displays the thermal baths of the villa of the wealthy Herod Atticus. Also in the complex is a restored villa, until 2002 a private residence, that has an exterior completely covered with pieces from Roman ruins, including pipes used in the baths. There are some very helpful staff to show you around, although they only speak Italian. An interesting photographic exhibition in the house traces the development of the Appian Way over the last century. Almost opposite the entrance to the baths is a ruined tower known as the Torre di Capo di Bove.
Built in the 9th century, this ancient basilica crowns the top of the Esquiline Hill. Tons of gold decorate the interior together with impressive mosaics (particularly when the floodlights are turned on), and there is a museum on the premises. If you are in Rome on Corpus Christi (Corpus Domini), which is the Thursday after the 8th Sunday after Easter, an early-evening service is held in San Giovanni by the Pope followed by a procession along Via Merulana to Santa Maria. Good opportunity for a close up view of the Pope. This is a very large church with lots to see, as for example, the main part of the church has two layers of mosaics and paintings high on the walls, the altar and apse are spectacular, and then there are several more or less large chapels you won't want to miss, including the one with the amazing golden baptismal font. Allow at least an hour if not an hour and a half or more to visit the interior, even if you do not take any special tours, and also allow time to view the exterior from all sides. Overall, at least 2 hours would not be too much time to allot.
Between the Pantheon and Via del Corso. A stunning example of Baroque art. The ceiling frescoes are especially fine, including a trompe l'oeil dome by the master Andrea Pozzo.
This museum is built on top of the excavation site of the Balbi Crypt, a building from the first century A.D. which underwent considerable modifications in the following centuries. Through the building's history, the museum gives us glimpses of what Roman life across the ages was like. Free visits of the ruins are possible. The Essedra ruins are only accessible on Saturdays and Sundays, at 10:45, 11:45, 12:45, 14:45 and 15:45.
Good collection of Renaissance and Baroque art, including by Velasquez, Titian, Raphael, and Bernini, all owned by the Doria Pamphilj family. Excellent audio guides really bring the paintings to life.
A relaxing place to sit and recover from the exertions of sightseeing. Permanent collection plus annual competition.